Alternative methods in toxicity testing: the current approach

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3R Principle and Alternative Toxicity Testing Methods

Toxicity tests are essential for evaluating the safety or hazards of several substances. Many of the current toxicity testing methods include the use of animals, especially rodents. However, in the last three decades, there has been an inclination towards using less animals and performing alternative methods that reduce, refine and replace animal use (3R principle). The viewpoint of “reduction”...

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Alternative methods for skin irritation testing: the current status.

The potential for chemicals to cause skin corrosion or skin irritation is an important consideration in establishing procedures for the safe handling, packing and transport of chemicals. The determination of skin corrosion and irritation potential is therefore included in international regulatory requirements for the testing of chemicals. The standard approach used involves applying the test ma...

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ژورنال

عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences

سال: 2014

ISSN: 1984-8250

DOI: 10.1590/s1984-82502011000100005